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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM125395'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM125395
PNG
(US8772480, 236)
Show SMILES COc1ccc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(O)c2ccc(cc2)S(=O)(=O)N(C)C)cn1
Show InChI InChI=1S/C24H26N8O4S/c1-14-28-23(31-24(25)29-14)19-11-16(12-27-22(19)30-17-7-10-20(36-4)26-13-17)21(33)15-5-8-18(9-6-15)37(34,35)32(2)3/h5-13,21,33H,1-4H3,(H,27,30)(H2,25,28,29,31)
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US Patent
4n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...


US Patent US8772480 (2014)


BindingDB Entry DOI: 10.7270/Q2V123FJ
More data for this
Ligand-Target Pair