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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM125410'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM125410
PNG
(US8772480, 255)
Show SMILES COc1ncc(Nc2nc(ccc2-c2nc(C)nc(N)n2)-c2cccnc2)cc1F
Show InChI InChI=1S/C20H17FN8O/c1-11-25-17(29-20(22)26-11)14-5-6-16(12-4-3-7-23-9-12)28-18(14)27-13-8-15(21)19(30-2)24-10-13/h3-10H,1-2H3,(H,27,28)(H2,22,25,26,29)
PDB
MMDB

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US Patent
4n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...


US Patent US8772480 (2014)


BindingDB Entry DOI: 10.7270/Q2V123FJ
More data for this
Ligand-Target Pair