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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM125443'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM125443
PNG
(US8772480, 298)
Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C2(O)CC2)cc1F
Show InChI InChI=1S/C18H18FN7O2/c1-9-23-15(26-17(20)24-9)12-5-10(18(27)3-4-18)7-21-14(12)25-11-6-13(19)16(28-2)22-8-11/h5-8,27H,3-4H2,1-2H3,(H,21,25)(H2,20,23,24,26)
PDB
MMDB

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US Patent
4n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...


US Patent US8772480 (2014)


BindingDB Entry DOI: 10.7270/Q2V123FJ
More data for this
Ligand-Target Pair