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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM125475'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM125475
PNG
(US8772480, 339)
Show SMILES CC(N1CCOCC1)c1cnc(Nc2cnc(Cl)c(NS(C)(=O)=O)c2)c(c1)-c1nc(C)nc2[nH]cnc12 |w:1.0|
Show InChI InChI=1S/C23H26ClN9O3S/c1-13(33-4-6-36-7-5-33)15-8-17(19-20-23(28-12-27-20)30-14(2)29-19)22(26-10-15)31-16-9-18(21(24)25-11-16)32-37(3,34)35/h8-13,32H,4-7H2,1-3H3,(H,26,31)(H,27,28,29,30)
PDB
MMDB

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US Patent
3n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...


US Patent US8772480 (2014)


BindingDB Entry DOI: 10.7270/Q2V123FJ
More data for this
Ligand-Target Pair