Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM127364'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM127364 (US8791131, 122) Show SMILES COC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O Show InChI InChI=1S/C26H24N6O3/c1-30-22-15-28-21-8-7-20(17-13-16-5-3-4-6-19(16)27-14-17)29-23(21)24(22)32(25(30)33)18-9-11-31(12-10-18)26(34)35-2/h3-8,13-15,18H,9-12H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.806	-51.9	n/a	n/a	n/a	n/a	n/a	7.4	25
Pfizer Inc. US Patent					Assay Description Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...				US Patent US8791131 (2014) BindingDB Entry DOI: 10.7270/Q23B5XV8
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