Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM50312610'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50312610 (6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...) Show SMILES CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2ccncc2)CC1 Show InChI InChI=1S/C21H26N6O3S2/c1-32(28,29)27-8-6-25(7-9-27)15-17-14-18-19(31-17)21(26-10-12-30-13-11-26)24-20(23-18)16-2-4-22-5-3-16/h2-5,14H,6-13,15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assay				J Med Chem 53: 1086-97 (2010) Article DOI: 10.1021/jm901284w BindingDB Entry DOI: 10.7270/Q2FJ2GXT
					More data for this Ligand-Target Pair