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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM50343235'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50343235
PNG
(CHEMBL1773077 | N-(6-(2-(3-Methoxybenzyloxy)pyrimi...)
Show SMILES COc1cccc(COc2nccc(n2)-c2ccc3nc(NC(C)=O)sc3c2)c1
Show InChI InChI=1S/C21H18N4O3S/c1-13(26)23-21-25-18-7-6-15(11-19(18)29-21)17-8-9-22-20(24-17)28-12-14-4-3-5-16(10-14)27-2/h3-11H,12H2,1-2H3,(H,23,25,26)
PDB
MMDB

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Article
PubMed
18n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha expressed in Sf9 cells


J Med Chem 54: 1789-811 (2011)


Article DOI: 10.1021/jm1014605
BindingDB Entry DOI: 10.7270/Q2TH8N1K
More data for this
Ligand-Target Pair