Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM50357642'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50357642 (CHEMBL1914712) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncccc2n1 Show InChI InChI=1S/C19H12ClFN4O2S/c20-19-18(25-28(26,27)14-5-3-13(21)4-6-14)10-12(11-23-19)15-7-8-16-17(24-15)2-1-9-22-16/h1-11,25H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser 473 in human U87MG cells				J Med Chem 54: 4735-51 (2011) Article DOI: 10.1021/jm200386s BindingDB Entry DOI: 10.7270/Q2FB53C5
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50357642 (CHEMBL1914712) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncccc2n1 Show InChI InChI=1S/C19H12ClFN4O2S/c20-19-18(25-28(26,27)14-5-3-13(21)4-6-14)10-12(11-23-19)15-7-8-16-17(24-15)2-1-9-22-16/h1-11,25H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	784	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser 473 in human U87MG cells				J Med Chem 54: 4735-51 (2011) Article DOI: 10.1021/jm200386s BindingDB Entry DOI: 10.7270/Q2FB53C5
					More data for this Ligand-Target Pair