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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Plasma kallikrein' and Ligand = 'BDBM50009178'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Plasma kallikrein


(Homo sapiens (Human))		BDBM50009178
PNG
(CHEMBL3238369)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2cccc(c2)C(N)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N |r|
Show InChI InChI=1S/C25H27N9O4/c1-32-19(13-34-20(35)14-33(25(34)38)18-7-4-5-15(9-18)21(28)36)10-16-12-29-22(31-23(16)32)24(37)30-17(11-27)6-2-3-8-26/h4-5,7,9-10,12,17H,2-3,6,8,13-14,26H2,1H3,(H2,28,36)(H,30,37)/t17-/m0/s1
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Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of human plasma kallikerin using H-D-Phe-Pro-Arg-pNA (S-2302) peptide as substrate assessed as reduction of enzyme hydrolytic activity

Bioorg Med Chem 22: 2339-52 (2014)


Article DOI: 10.1016/j.bmc.2014.02.002
BindingDB Entry DOI: 10.7270/Q2KH0PVJ
More data for this
Ligand-Target Pair