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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Plasminogen' and Ligand = 'BDBM108118'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen


(Homo sapiens (Human))
BDBM108118
PNG
(US8598206, Table 6, 1)
Show SMILES NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCCn2cnnn2)NS(=O)(=O)Cc2ccccc2)cc1 |r|
Show InChI InChI=1S/C30H42N10O4S/c31-28(32)25-11-8-23(9-12-25)19-34-29(41)26(13-10-22-14-16-33-17-15-22)36-30(42)27(7-4-18-40-21-35-38-39-40)37-45(43,44)20-24-5-2-1-3-6-24/h1-3,5-6,8-9,11-12,21-22,26-27,33,37H,4,7,10,13-20H2,(H3,31,32)(H,34,41)(H,36,42)/t26-,27+/m0/s1
PDB
MMDB

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US Patent
8n/an/an/an/an/an/an/an/a



The Medicines Company (Leipzig) GmbH

US Patent


Assay Description
The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...


US Patent US8598206 (2013)


BindingDB Entry DOI: 10.7270/Q25T3J5F
More data for this
Ligand-Target Pair