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Found 2 hits Enz. Inhib. hit(s) with Target = 'Platelet-activating factor acetylhydrolase IB subunit beta' and Ligand = 'BDBM50188241'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-activating factor acetylhydrolase IB subunit beta


(Homo sapiens (Human))
BDBM50188241
PNG
(CHEMBL3828121)
Show SMILES COCCN(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(N)=O)C(=O)CN(NC(=O)Nc1ccccc1)C(=O)CN(NC(=O)c1ccc(Cl)cc1)C(=O)CNNC(=O)c1ccc(s1)-c1ccc(Br)cc1
Show InChI InChI=1S/C48H61BrClN13O10S/c1-73-26-25-61(30-43(67)60(24-8-6-22-52)29-42(66)59(28-40(53)64)23-7-5-21-51)44(68)31-63(58-48(72)55-37-9-3-2-4-10-37)45(69)32-62(57-46(70)34-13-17-36(50)18-14-34)41(65)27-54-56-47(71)39-20-19-38(74-39)33-11-15-35(49)16-12-33/h2-4,9-20,54H,5-8,21-32,51-52H2,1H3,(H2,53,64)(H,56,71)(H,57,70)(H2,55,58,72)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
PubMed
n/an/a 3.40E+4n/an/an/an/an/an/a



Shiv Nadar University

Curated by ChEMBL


Assay Description
Inhibition of PAFAH1B2 (unknown origin) using 2-thiol-PAF as substrate by Ellman's assay


Bioorg Med Chem 24: 3953-3963 (2016)

More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase IB subunit beta


(Homo sapiens (Human))
BDBM50188241
PNG
(CHEMBL3828121)
Show SMILES COCCN(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(N)=O)C(=O)CN(NC(=O)Nc1ccccc1)C(=O)CN(NC(=O)c1ccc(Cl)cc1)C(=O)CNNC(=O)c1ccc(s1)-c1ccc(Br)cc1
Show InChI InChI=1S/C48H61BrClN13O10S/c1-73-26-25-61(30-43(67)60(24-8-6-22-52)29-42(66)59(28-40(53)64)23-7-5-21-51)44(68)31-63(58-48(72)55-37-9-3-2-4-10-37)45(69)32-62(57-46(70)34-13-17-36(50)18-14-34)41(65)27-54-56-47(71)39-20-19-38(74-39)33-11-15-35(49)16-12-33/h2-4,9-20,54H,5-8,21-32,51-52H2,1H3,(H2,53,64)(H,56,71)(H,57,70)(H2,55,58,72)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
PubMed
n/an/a 3.80E+4n/an/an/an/an/an/a



Shiv Nadar University

Curated by ChEMBL


Assay Description
Time-dependent inhibition of PAFAH1B2 (unknown origin) using 2-thiol-PAF as substrate by Ellman's assay


Bioorg Med Chem 24: 3953-3963 (2016)

More data for this
Ligand-Target Pair