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Found 2 hits Enz. Inhib. hit(s) with Target = 'Platelet-activating factor acetylhydrolase IB subunit beta' and Ligand = 'BDBM50188242'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-activating factor acetylhydrolase IB subunit beta


(Homo sapiens (Human))
BDBM50188242
PNG
(CHEMBL3827685)
Show SMILES COCCN(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(N)=O)C(=O)CN(NC(=O)Nc1ccc(cc1)N(C)C)C(=O)CN(NC(=O)c1ccc(Cl)cc1)C(=O)Cn1nc(oc1=O)-c1ccc(s1)-c1ccc(Br)cc1
Show InChI InChI=1S/C51H64BrClN14O11S/c1-61(2)39-18-16-38(17-19-39)57-50(75)60-66(31-45(71)64(26-27-77-3)30-44(70)63(25-7-5-23-55)29-43(69)62(28-42(56)68)24-6-4-22-54)46(72)32-65(58-48(74)35-10-14-37(53)15-11-35)47(73)33-67-51(76)78-49(59-67)41-21-20-40(79-41)34-8-12-36(52)13-9-34/h8-21H,4-7,22-33,54-55H2,1-3H3,(H2,56,68)(H,58,74)(H2,57,60,75)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Shiv Nadar University

Curated by ChEMBL


Assay Description
Time-dependent inhibition of PAFAH1B2 (unknown origin) using 2-thiol-PAF as substrate by Ellman's assay


Bioorg Med Chem 24: 3953-3963 (2016)

More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase IB subunit beta


(Homo sapiens (Human))
BDBM50188242
PNG
(CHEMBL3827685)
Show SMILES COCCN(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(N)=O)C(=O)CN(NC(=O)Nc1ccc(cc1)N(C)C)C(=O)CN(NC(=O)c1ccc(Cl)cc1)C(=O)Cn1nc(oc1=O)-c1ccc(s1)-c1ccc(Br)cc1
Show InChI InChI=1S/C51H64BrClN14O11S/c1-61(2)39-18-16-38(17-19-39)57-50(75)60-66(31-45(71)64(26-27-77-3)30-44(70)63(25-7-5-23-55)29-43(69)62(28-42(56)68)24-6-4-22-54)46(72)32-65(58-48(74)35-10-14-37(53)15-11-35)47(73)33-67-51(76)78-49(59-67)41-21-20-40(79-41)34-8-12-36(52)13-9-34/h8-21H,4-7,22-33,54-55H2,1-3H3,(H2,56,68)(H,58,74)(H2,57,60,75)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Shiv Nadar University

Curated by ChEMBL


Assay Description
Inhibition of PAFAH1B2 (unknown origin) using 2-thiol-PAF as substrate by Ellman's assay


Bioorg Med Chem 24: 3953-3963 (2016)

More data for this
Ligand-Target Pair