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Found 1 hit Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor beta' and Ligand = 'BDBM4171'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4171
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7d | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl |(-9.18,1.13,;-10.52,.36,;-10.52,-1.18,;-11.85,-1.95,;-13.19,-1.18,;-9.18,-1.95,;-7.85,-1.18,;-6.52,-1.95,;-5.18,-1.18,;-3.85,-1.95,;-2.52,-1.12,;-1.18,-1.89,;-1.18,-3.43,;.15,-1.12,;1.48,-1.89,;.15,.42,;-1.18,1.19,;-2.52,.42,;-3.85,1.13,;-5.18,.36,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,)|
Show InChI InChI=1S/C21H24Cl2N4O/c1-4-27(5-2)10-9-24-19-12-18-14(13-25-19)11-15(21(28)26(18)3)20-16(22)7-6-8-17(20)23/h6-8,11-13H,4-5,9-10H2,1-3H3,(H,24,25)
PDB
MMDB

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Patents


Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair