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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor beta' and Ligand = 'BDBM4899'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4899
PNG
(3-(5-{[(3Z)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3...)
Show SMILES COc1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1
Show InChI InChI=1S/C19H20N2O4/c1-10-13(6-7-18(22)23)11(2)20-16(10)9-15-14-5-4-12(25-3)8-17(14)21-19(15)24/h4-5,8-9,20H,6-7H2,1-3H3,(H,21,24)(H,22,23)/b15-9-
PDB
MMDB

NCI pathway
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PC cid
PC sid
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Patents

Article
PubMed
n/an/a 550n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 42: 5120-30 (1999)


Article DOI: 10.1006/jmbi.2001.4516
BindingDB Entry DOI: 10.7270/Q20Z71GM
More data for this
Ligand-Target Pair