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Found 1 hit Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase 1' and Ligand = 'BDBM50306192'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50306192
PNG
(2-(4-(azetidine-3-carboxamido)phenyl)-2H-indazole-...)
Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(NC(=O)C2CNC2)cc1
Show InChI InChI=1S/C18H17N5O2/c19-17(24)15-3-1-2-11-10-23(22-16(11)15)14-6-4-13(5-7-14)21-18(25)12-8-20-9-12/h1-7,10,12,20H,8-9H2,(H2,19,24)(H,21,25)
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



IRBM-Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assay

Bioorg Med Chem Lett 20: 488-92 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.127
BindingDB Entry DOI: 10.7270/Q2W37WFZ
More data for this
Ligand-Target Pair