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Found 1 hit Enz. Inhib. hit(s) with Target = 'Polymerase basic protein 2' and Ligand = 'BDBM50050721'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polymerase basic protein 2


(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)		BDBM50050721
PNG
(CHEMBL3317973)
Show SMILES CC(=O)N1CCC[C@H](CNc2nc(ncc2F)-c2c[nH]c3ncc(Cl)cc23)C1 |r|
Show InChI InChI=1S/C19H20ClFN6O/c1-11(28)27-4-2-3-12(10-27)6-22-19-16(21)9-25-18(26-19)15-8-24-17-14(15)5-13(20)7-23-17/h5,7-9,12H,2-4,6,10H2,1H3,(H,23,24)(H,22,25,26)/t12-/m1/s1
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Article
PubMed
n/an/an/a 300n/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay

J Med Chem 57: 6668-78 (2014)


Article DOI: 10.1021/jm5007275
BindingDB Entry DOI: 10.7270/Q2R21316
More data for this
Ligand-Target Pair