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Target
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Found
3
hits Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily H member 2' and Ligand = 'BDBM50391770'
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
BDBM50391770
(CHEMBL2146755 | US9073882, 1)
Show SMILES
[O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)[N+]([O-])=O)CC2)cc1
Show InChI
InChI=1S/C20H24N4O4/c25-23(26)19-5-1-17(2-6-19)9-11-21-13-15-22(16-14-21)12-10-18-3-7-20(8-4-18)24(27)28/h1-8H,9-16H2
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
CHEMBL
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
5
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Curated by
ChEMBL
Assay Description
Displacement of [35S]MK499 from human ERG
ACS Med Chem Lett
3:
367
-
372
(2012)
Article DOI:
10.1021/ml3000066
BindingDB Entry DOI:
10.7270/Q2MK6DZV
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
BDBM50391770
(CHEMBL2146755 | US9073882, 1)
Show SMILES
[O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)[N+]([O-])=O)CC2)cc1
Show InChI
InChI=1S/C20H24N4O4/c25-23(26)19-5-1-17(2-6-19)9-11-21-13-15-22(16-14-21)12-10-18-3-7-20(8-4-18)24(27)28/h1-8H,9-16H2
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
CHEMBL
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
7
n/a
n/a
n/a
n/a
n/a
n/a
Merck Research Laboratories
Curated by
ChEMBL
Assay Description
Displacement of [35S]MK-499 from human ERG
ACS Med Chem Lett
7:
697
-
701
(2016)
Article DOI:
10.1021/acsmedchemlett.6b00122
BindingDB Entry DOI:
10.7270/Q25X2DF1
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
BDBM50391770
(CHEMBL2146755 | US9073882, 1)
Show SMILES
[O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)[N+]([O-])=O)CC2)cc1
Show InChI
InChI=1S/C20H24N4O4/c25-23(26)19-5-1-17(2-6-19)9-11-21-13-15-22(16-14-21)12-10-18-3-7-20(8-4-18)24(27)28/h1-8H,9-16H2
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
CHEMBL
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
7
n/a
n/a
n/a
n/a
n/a
n/a
Merck Research Laboratories
Curated by
ChEMBL
Assay Description
Displacement of [35S]MK-499 from human ERG
ACS Med Chem Lett
7:
697
-
701
(2016)
Article DOI:
10.1021/acsmedchemlett.6b00122
BindingDB Entry DOI:
10.7270/Q25X2DF1
More data for this
Ligand-Target Pair
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