Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Progesterone receptor (Rattus norvegicus) | BDBM18525 (Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. | Assay Description The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd] where [L] is the concentration of labeled ligand a... | J Med Chem 49: 716-26 (2006) Article DOI: 10.1021/jm050293c BindingDB Entry DOI: 10.7270/Q2P84952 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM18525 (Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Antagonistic activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells. | J Med Chem 41: 623-39 (1998) Article DOI: 10.1021/jm970699s BindingDB Entry DOI: 10.7270/Q2VM4CZ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Oryctolagus cuniculus) | BDBM18525 (Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Displacement of [3H]progesterone from progesterone receptor in JW rabbit uterus after 2 hrs by liquid scintillation counting | Bioorg Med Chem Lett 21: 6310-3 (2011) Checked by Author Article DOI: 10.1016/j.bmcl.2011.08.118 BindingDB Entry DOI: 10.7270/Q2JH3MKZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Oryctolagus cuniculus) | BDBM18525 (Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Displacement of [3H]progesterone from rabbit PR by liquid scintillation counting | Bioorg Med Chem Lett 21: 1744-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.073 BindingDB Entry DOI: 10.7270/Q2474B55 | |||||||||||
More data for this Ligand-Target Pair |