Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM336960 (US9745291, Compound 6 | US9765068, Compound 6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i... | Citation and Details Article DOI: 10.1021/acsmedchemlett.5b00380 BindingDB Entry DOI: 10.7270/Q2SQ941H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM336960 (US9745291, Compound 6 | US9765068, Compound 6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan... | US Patent US9765068 (2017) BindingDB Entry DOI: 10.7270/Q2959KN3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |