Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteinase-activated receptor 1 (Homo sapiens (Human)) | BDBM50386408 (CHEMBL2047297) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte... | ACS Med Chem Lett 3: 232-237 (2012) Article DOI: 10.1021/ml2002696 BindingDB Entry DOI: 10.7270/Q2Q52QP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteinase-activated receptor 1 (Homo sapiens (Human)) | BDBM50386408 (CHEMBL2047297) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Marquette University Curated by ChEMBL | Assay Description Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ... | Bioorg Med Chem 26: 2514-2529 (2018) Article DOI: 10.1016/j.bmc.2018.04.016 BindingDB Entry DOI: 10.7270/Q23R0WHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteinase-activated receptor 1 (Homo sapiens (Human)) | BDBM50386408 (CHEMBL2047297) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Marquette University Curated by ChEMBL | Assay Description Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate... | Bioorg Med Chem 27: 3788-3796 (2019) Article DOI: 10.1016/j.bmc.2019.06.043 BindingDB Entry DOI: 10.7270/Q2MP56MJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteinase-activated receptor 1 (Homo sapiens (Human)) | BDBM50386408 (CHEMBL2047297) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Marquette University Curated by ChEMBL | Assay Description Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ... | Bioorg Med Chem 26: 2514-2529 (2018) Article DOI: 10.1016/j.bmc.2018.04.016 BindingDB Entry DOI: 10.7270/Q23R0WHM | |||||||||||
More data for this Ligand-Target Pair |