BindingDB PrimarySearch

Found 10 hits Enz. Inhib. hit(s) with Target = 'Prothrombin' and Ligand = 'BDBM50038002'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prothrombin (Homo sapiens (Human))	BDBM50038002 (Benzamidine (Protonated) \| CHEMBL20936 \| CHEMBL537...) Show SMILES NC(=N)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description In vitro binding affinity by measuring the inhibition of human thrombin				J Med Chem 37: 3889-901 (1994) BindingDB Entry DOI: 10.7270/Q25X29KK
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50038002 (Benzamidine (Protonated) \| CHEMBL20936 \| CHEMBL537...) Show SMILES NC(=N)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma KG Curated by ChEMBL					Assay Description Inhibitory Activity against human thrombin				J Med Chem 43: 3033-44 (2000) BindingDB Entry DOI: 10.7270/Q20R9Q3N
Boehringer Ingelheim Pharma KG Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50038002 (Benzamidine (Protonated) \| CHEMBL20936 \| CHEMBL537...) Show SMILES NC(=N)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	PubMed	1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Binding affinity against human thrombin				J Med Chem 45: 2469-83 (2002) BindingDB Entry DOI: 10.7270/Q28916J7
University of Parma Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50038002 (Benzamidine (Protonated) \| CHEMBL20936 \| CHEMBL537...) Show SMILES NC(=N)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	PubMed	1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Binding affinity against human thrombin				J Med Chem 45: 2469-83 (2002) BindingDB Entry DOI: 10.7270/Q28916J7
University of Parma Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50038002 (Benzamidine (Protonated) \| CHEMBL20936 \| CHEMBL537...) Show SMILES NC(=N)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
TBA Curated by ChEMBL					Assay Description Tested for the Inhibition of the catalytic activity of human Thrombin at 25 degree C and pH 7.5.				Bioorg Med Chem Lett 7: 1283-1288 (1997) Article DOI: 10.1016/S0960-894X(97)00210-2 BindingDB Entry DOI: 10.7270/Q29W0FZ9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50038002 (Benzamidine (Protonated) \| CHEMBL20936 \| CHEMBL537...) Show SMILES NC(=N)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	2.58E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps-University Marburg Curated by ChEMBL					Assay Description Binding affinity to thrombin (unknown origin)				J Med Chem 58: 6960-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00812 BindingDB Entry DOI: 10.7270/Q26M38M6
Philipps-University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50038002 (Benzamidine (Protonated) \| CHEMBL20936 \| CHEMBL537...) Show SMILES NC(=N)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	PubMed	3.16E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of esterase activity of human plasmin assessed as assessed as decrease in p-nitrophenol production using N-Z-L-Tyr-ONp as subs...				J Med Chem 21: 1202-7 (1979) BindingDB Entry DOI: 10.7270/Q2ST7RCQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Bos taurus (Bovine))	BDBM50038002 (Benzamidine (Protonated) \| CHEMBL20936 \| CHEMBL537...) Show SMILES NC(=N)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	8.90E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institut für Biochemie Curated by ChEMBL					Assay Description Inhibitory activity against bovine thrombin expressed as dissociation constant				J Med Chem 41: 5445-56 (1999) Article DOI: 10.1021/jm981068g BindingDB Entry DOI: 10.7270/Q2KK99ZF
Institut für Biochemie Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50038002 (Benzamidine (Protonated) \| CHEMBL20936 \| CHEMBL537...) Show SMILES NC(=N)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	3.55E+5	n/a	n/a	n/a	n/a	n/a
Philipps-University Marburg Curated by ChEMBL					Assay Description Binding affinity to thrombin (unknown origin) by direct isothermal titration colorimetry				J Med Chem 58: 6960-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00812 BindingDB Entry DOI: 10.7270/Q26M38M6
Philipps-University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50038002 (Benzamidine (Protonated) \| CHEMBL20936 \| CHEMBL537...) Show SMILES NC(=N)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	4.55E+5	n/a	n/a	n/a	n/a	n/a
Philipps-University Marburg Curated by ChEMBL					Assay Description Binding affinity to thrombin (unknown origin) by displacement titration based isothermal titration colorimetry				J Med Chem 58: 6960-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00812 BindingDB Entry DOI: 10.7270/Q26M38M6
Philipps-University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair