BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Purine nucleoside phosphorylase' and Ligand = 'BDBM50022243'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Purine nucleoside phosphorylase (Rattus norvegicus)	BDBM50022243 (2,8-Diamino-1,9-dihydro-purin-6-one \| 8-AMINOGUANI...) Show SMILES Nc1nc2nc(N)[nH]c(=O)c2[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP)				J Med Chem 37: 2477-80 (1994) BindingDB Entry DOI: 10.7270/Q21G0K9T
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50022243 (2,8-Diamino-1,9-dihydro-purin-6-one \| 8-AMINOGUANI...) Show SMILES Nc1nc2nc(N)[nH]c(=O)c2[nH]1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	681	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using 2-amino-6-mercapto-7-methyl purine ribonucleoside (MESG) as subst...				J Med Chem 42: 2422-31 (1999) Article DOI: 10.1021/jm990037y BindingDB Entry DOI: 10.7270/Q2CR5SKN
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50022243 (2,8-Diamino-1,9-dihydro-purin-6-one \| 8-AMINOGUANI...) Show SMILES Nc1nc2nc(N)[nH]c(=O)c2[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Defense Medical Center Curated by ChEMBL					Assay Description PNP activity in human RBC				J Med Chem 36: 1024-31 (1993) BindingDB Entry DOI: 10.7270/Q2CV4JCQ
National Defense Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50022243 (2,8-Diamino-1,9-dihydro-purin-6-one \| 8-AMINOGUANI...) Show SMILES Nc1nc2nc(N)[nH]c(=O)c2[nH]1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	982	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.				J Med Chem 42: 2422-31 (1999) Article DOI: 10.1021/jm990037y BindingDB Entry DOI: 10.7270/Q2CR5SKN
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50022243 (2,8-Diamino-1,9-dihydro-purin-6-one \| 8-AMINOGUANI...) Show SMILES Nc1nc2nc(N)[nH]c(=O)c2[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibition of purine nucleoside phosphorylase using human erythro lysate				J Med Chem 29: 2034-7 (1986) BindingDB Entry DOI: 10.7270/Q29P326Z
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50022243 (2,8-Diamino-1,9-dihydro-purin-6-one \| 8-AMINOGUANI...) Show SMILES Nc1nc2nc(N)[nH]c(=O)c2[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for 50% inhibition of purine nucleoside phosphorylase activity by was measured by the conversion of [8-14C]-inosine to [8-14C]...				J Med Chem 29: 1804-6 (1986) BindingDB Entry DOI: 10.7270/Q2F76D5J
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50022243 (2,8-Diamino-1,9-dihydro-purin-6-one \| 8-AMINOGUANI...) Show SMILES Nc1nc2nc(N)[nH]c(=O)c2[nH]1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.				J Med Chem 42: 2422-31 (1999) Article DOI: 10.1021/jm990037y BindingDB Entry DOI: 10.7270/Q2CR5SKN
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair