Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human DoHH2 cells using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of human recombinant PNP using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human Jurkat cells using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human PBMC using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human K562 cells using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human MINO cells using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human MC116 cells using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human SU-DHL-1 cells using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human AML cells obtained from patients using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human CML cells obtained from patients using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human OPM2 cells using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human HBL2 cells using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human RPMI8226 cells using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Competitive inhibition of PNP in human HBL2 tumor cells using MSEG as substrate by Dixon-plot analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50382672 (CHEMBL2024005) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Inhibition of human recombinant PNP using MSEG as substrate preincubated with inhibitor within 10 to 20 mins measured after 5 mins by HPLC analysis | J Med Chem 55: 1612-21 (2012) Article DOI: 10.1021/jm201409u BindingDB Entry DOI: 10.7270/Q2VX0HJ2 | |||||||||||
More data for this Ligand-Target Pair |