BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = 'Rap guanine nucleotide exchange factor 3' and Ligand = 'BDBM50011360'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of EPAC1 (unknown origin)				Bioorg Med Chem Lett 27: 1633-1639 (2017) Article DOI: 10.1016/j.bmcl.2017.02.065 BindingDB Entry DOI: 10.7270/Q2FF3VXQ
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of EPAC1 (unknown origin) assessed as cAMP-mediated GEF activity				J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...				Bioorg Med Chem Lett 27: 5163-5166 (2017) Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of recombinant C-terminal FLAG/HA-tagged EPAC1 (unknown origin) expressed in retrovirus infected human HeLaS3 cells assessed as reduction ...				ACS Med Chem Lett 7: 460-4 (2016) Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at EPAC1 (unknown origin) assessed as cAMP-induced guanine nucleotide exchange factor activity				J Med Chem 58: 6033-47 (2015) Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a
University Health Network Curated by ChEMBL					Assay Description Inhibition of 8-NBD-cAMP binding to human EPAC1 cAMP binding domain (149 to 318 residues) by fluorescence assay				J Med Chem 62: 5063-5079 (2019) Article DOI: 10.1021/acs.jmedchem.9b00258 BindingDB Entry DOI: 10.7270/Q2988BF5
University Health Network Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a
University Health Network Curated by ChEMBL					Assay Description Binding affinity to human EPAC1 cAMP binding domain (149 to 318 residues) using aggregate form of compound by [15N-1H]HSQC spectroscopic analysis				J Med Chem 62: 5063-5079 (2019) Article DOI: 10.1021/acs.jmedchem.9b00258 BindingDB Entry DOI: 10.7270/Q2988BF5
University Health Network Curated by ChEMBL					More data for this Ligand-Target Pair