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Found 1 hit Enz. Inhib. hit(s) with Target = 'Receptor tyrosine-protein kinase erbB-2' and Ligand = 'BDBM50358441'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50358441
PNG
(CHEMBL1922906)
Show SMILES FC(F)(F)Oc1ccccc1Oc1ccc(Nc2ncnc3cc[nH]c23)cc1Cl
Show InChI InChI=1S/C19H12ClF3N4O2/c20-12-9-11(27-18-17-13(7-8-24-17)25-10-26-18)5-6-14(12)28-15-3-1-2-4-16(15)29-19(21,22)23/h1-10,24H,(H,25,26,27)
PDB
MMDB

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Similars
Article
PubMed
n/an/a 55n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of human N-terminus peptide (DYKDDDD)-tagged HER2 expressed in baculovirus infected insect cells using [gamma-32P]ATP as substrate after 6...

J Med Chem 54: 8030-50 (2011)


Article DOI: 10.1021/jm2008634
BindingDB Entry DOI: 10.7270/Q23R0T93
More data for this
Ligand-Target Pair