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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Renal Outer Medullary Potassium (ROMK)' and Ligand = 'BDBM162873'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))
BDBM162873
PNG
(US9056859, 96)
Show SMILES Cc1c2COC(=O)c2ccc1CCN1CCN(CC1)C(=O)C1CCc2nc(ccc12)-n1cnnn1
Show InChI InChI=1/C25H27N7O3/c1-16-17(2-3-20-21(16)14-35-25(20)34)8-9-30-10-12-31(13-11-30)24(33)19-4-6-22-18(19)5-7-23(27-22)32-15-26-28-29-32/h2-3,5,7,15,19H,4,6,8-14H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 61n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9056859 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XS0
More data for this
Ligand-Target Pair