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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Renal Outer Medullary Potassium (ROMK)' and Ligand = 'BDBM162874'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Renal Outer Medullary Potassium (ROMK)


(Rattus norvegicus (Rat))
BDBM162874
PNG
(US9056859, 122)
Show SMILES Cc1c(CCN2CCN(CC2)C(=O)Cc2ccc(cc2)-n2cnnn2)ccc(F)c1[N+]#[C-]
Show InChI InChI=1S/C23H24FN7O/c1-17-19(5-8-21(24)23(17)25-2)9-10-29-11-13-30(14-12-29)22(32)15-18-3-6-20(7-4-18)31-16-26-27-28-31/h3-8,16H,9-15H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/a7.4n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9056859 (2015)


BindingDB Entry DOI: 10.7270/Q20P0XS0
More data for this
Ligand-Target Pair