BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1a' and Ligand = 'BDBM50007789'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Replicase polyprotein 1a (Human SARS coronavirus (SARS-CoV))	BDBM50007789 (CHEMBL1173044 \| GRL-0667 \| N-(2H-1,3-benzodioxol-5...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn					Assay Description This is a review article.				Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6
University of Bonn					More data for this Ligand-Target Pair				3D Structure (crystal)
Replicase polyprotein 1a (Human coronavirus NL63)	BDBM50007789 (CHEMBL1173044 \| GRL-0667 \| N-(2H-1,3-benzodioxol-5...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC rele...				J Med Chem 57: 2393-412 (2014) Article DOI: 10.1021/jm401712t BindingDB Entry DOI: 10.7270/Q2KK9DBM
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair