Found 7 hits Enz. Inhib. hit(s) with Target = 'Retinol-binding protein 4' and Ligand = 'BDBM50019040' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Retinol-binding protein 4
(Homo sapiens (Human)) | BDBM50019040
(CHEMBL1230001)Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 0.155 | n/a | n/a | n/a | n/a | n/a | n/a |
Albany Molecular Research
Curated by ChEMBL
| Assay Description Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p... |
J Med Chem 57: 7731-57 (2014)
Article DOI: 10.1021/jm5010013 BindingDB Entry DOI: 10.7270/Q2FB54JT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Retinol-binding protein 4
(Homo sapiens (Human)) | BDBM50019040
(CHEMBL1230001)Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant RBP4-transthyretin interaction by FRET analysis |
Bioorg Med Chem Lett 24: 2885-91 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.089 BindingDB Entry DOI: 10.7270/Q2154JMV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Retinol-binding protein 4
(Homo sapiens (Human)) | BDBM50019040
(CHEMBL1230001)Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Albany Molecular Research
Curated by ChEMBL
| Assay Description Displacement of [3H]retinol from biotinylated human RBP4 by scintillation proximity assay |
J Med Chem 57: 7731-57 (2014)
Article DOI: 10.1021/jm5010013 BindingDB Entry DOI: 10.7270/Q2FB54JT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Retinol-binding protein 4
(Homo sapiens (Human)) | BDBM50019040
(CHEMBL1230001)Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University Medical Center
Curated by ChEMBL
| Assay Description Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay |
J Med Chem 58: 5863-88 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00423 BindingDB Entry DOI: 10.7270/Q20Z751F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Retinol-binding protein 4
(Homo sapiens (Human)) | BDBM50019040
(CHEMBL1230001)Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
| Assay Description Competitive displacement of 3[H]retinol from biotinylated RBP4 (unknown origin) by surface plasmon resonance analysis |
J Med Chem 62: 5470-5500 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00352 BindingDB Entry DOI: 10.7270/Q290272Z |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Retinol-binding protein 4
(Homo sapiens (Human)) | BDBM50019040
(CHEMBL1230001)Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-retinol from human recombinant RBP4 by scintillation proximity assay |
Bioorg Med Chem Lett 24: 2885-91 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.089 BindingDB Entry DOI: 10.7270/Q2154JMV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Retinol-binding protein 4
(Homo sapiens (Human)) | BDBM50019040
(CHEMBL1230001)Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University Medical Center
Curated by ChEMBL
| Assay Description Inhibition of retinol-induced interaction of bacterially expressed MBP-tagged RBP4 (unknown origin) with Eu3+ cryptate labeled TTR by HTRF assay |
J Med Chem 58: 5863-88 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00423 BindingDB Entry DOI: 10.7270/Q20Z751F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |