Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM50104159 (CHEMBL3594229 | US10787453, Compound 66) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University Medical Center Curated by ChEMBL | Assay Description Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay | J Med Chem 58: 5863-88 (2015) Article DOI: 10.1021/acs.jmedchem.5b00423 BindingDB Entry DOI: 10.7270/Q20Z751F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM50104159 (CHEMBL3594229 | US10787453, Compound 66) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
The Trustees of Columbia University in the City of New York US Patent | Assay Description Compound 65 and 66 were tested in two in vitro assays, RBP4 binding (SPA) and retinol-dependent RBP4-TTR interaction (HTRF). The compounds binded to ... | US Patent US10787453 (2020) BindingDB Entry DOI: 10.7270/Q2GH9N1V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM50104159 (CHEMBL3594229 | US10787453, Compound 66) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University Medical Center Curated by ChEMBL | Assay Description Inhibition of retinol-induced interaction of bacterially expressed MBP-tagged RBP4 (unknown origin) with Eu3+ cryptate labeled TTR by HTRF assay | J Med Chem 58: 5863-88 (2015) Article DOI: 10.1021/acs.jmedchem.5b00423 BindingDB Entry DOI: 10.7270/Q20Z751F | |||||||||||
More data for this Ligand-Target Pair |