BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Ribosomal protein S6 kinase alpha-3' and Ligand = 'BDBM50248765'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50248765 (1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of RSK2 after 60 mins				J Med Chem 54: 3564-74 (2011) Article DOI: 10.1021/jm200139j BindingDB Entry DOI: 10.7270/Q26M374H
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50248765 (1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Covalution Pharma BV Curated by ChEMBL					Assay Description Inhibition of RSK2 transfected in HEK293 cells				J Med Chem 55: 6243-62 (2012) Article DOI: 10.1021/jm3003203 BindingDB Entry DOI: 10.7270/Q2X92CGP
Covalution Pharma BV Curated by ChEMBL					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50248765 (1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of His6-tagged RSK2 C-terminal domian expressed in Escherichia coli after 30 mins				Nat Chem Biol 3: 156-60 (2007) Article DOI: 10.1038/nchembio859 BindingDB Entry DOI: 10.7270/Q22B8Z60
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50248765 (1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of RSK2 (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00969 BindingDB Entry DOI: 10.7270/Q2WD44DC
TBA					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50248765 (1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of His6x-tagged RSK2 C-terminal domain (unknown origin) expressed in Escherichia coli				Bioorg Med Chem 21: 1724-34 (2013) Article DOI: 10.1016/j.bmc.2013.01.047 BindingDB Entry DOI: 10.7270/Q2GQ704N
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50248765 (1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of RSK2 C-terminal kinase domain (unknown origin) expressed in Escherichia coli preincubated for 30 mins				Science 308: 1318-21 (2005) Article DOI: 10.1126/science1108367 BindingDB Entry DOI: 10.7270/Q20G3JX9
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM50248765 (1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of PMA-stimulated RSK2 phosphorylation in HEK293 cells after 1 hr by western blotting analysis				Nat Chem Biol 3: 156-60 (2007) Article DOI: 10.1038/nchembio859 BindingDB Entry DOI: 10.7270/Q22B8Z60
University of California Curated by ChEMBL					More data for this Ligand-Target Pair