Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Chk1' and Ligand = 'BDBM50245178'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50245178 (6-(3-(1H-imidazol-1-yl)propyl)-4-(2,6-dichlorophen...) Show SMILES Oc1ccc2n(CCCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(17.41,2.71,;18.74,1.94,;18.74,.39,;20.07,-.38,;21.42,.39,;22.89,-.08,;23.38,-1.54,;22.36,-2.69,;22.84,-4.15,;21.82,-5.3,;22.15,-6.81,;20.82,-7.59,;19.67,-6.57,;20.29,-5.15,;23.79,1.18,;25.33,1.35,;25.95,2.77,;25.02,4.01,;25.33,5.52,;26.73,6.15,;24,6.28,;22.86,5.24,;21.35,5.55,;23.49,3.84,;22.88,2.43,;21.41,1.94,;20.07,2.71,;27.48,2.95,;28.39,1.7,;27.78,.29,;29.92,1.88,;30.53,3.29,;29.61,4.53,;28.08,4.35,;28.07,5.9,)| Show InChI InChI=1S/C26H18Cl2N4O3/c27-17-3-1-4-18(28)21(17)16-12-20-22(24-23(16)25(34)30-26(24)35)15-11-14(33)5-6-19(15)32(20)9-2-8-31-10-7-29-13-31/h1,3-7,10-13,33H,2,8-9H2,(H,30,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determination				Eur J Med Chem 43: 1276-96 (2008) Article DOI: 10.1016/j.ejmech.2007.07.016 BindingDB Entry DOI: 10.7270/Q26M36MC
					More data for this Ligand-Target Pair