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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Chk1' and Ligand = 'BDBM50433495'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50433495
PNG
(CHEMBL2381113)
Show SMILES O=C(Nc1cnccc1N1CCNCC1)c1csc(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H23N5O2S/c31-24(28-21-16-27-11-10-23(21)30-14-12-26-13-15-30)22-17-33-25(29-22)18-6-8-20(9-7-18)32-19-4-2-1-3-5-19/h1-11,16-17,26H,12-15H2,(H,28,31)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...

Bioorg Med Chem Lett 23: 2590-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.108
BindingDB Entry DOI: 10.7270/Q2125V19
More data for this
Ligand-Target Pair