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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Chk1' and Ligand = 'BDBM50433509'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50433509
PNG
(CHEMBL2381240)
Show SMILES O=C(Nc1ccccc1N1CCNCC1)c1csc(n1)N1Cc2ccncc2C1
Show InChI InChI=1S/C21H22N6OS/c28-20(24-17-3-1-2-4-19(17)26-9-7-22-8-10-26)18-14-29-21(25-18)27-12-15-5-6-23-11-16(15)13-27/h1-6,11,14,22H,7-10,12-13H2,(H,24,28)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...

Bioorg Med Chem Lett 23: 2590-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.108
BindingDB Entry DOI: 10.7270/Q2125V19
More data for this
Ligand-Target Pair