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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Chk1' and Ligand = 'BDBM50433516'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50433516
PNG
(CHEMBL2381232)
Show SMILES O=C(Nc1ccccc1N1CCNCC1)c1csc(n1)N1CCCc2ccccc12
Show InChI InChI=1S/C23H25N5OS/c29-22(25-18-8-2-4-10-21(18)27-14-11-24-12-15-27)19-16-30-23(26-19)28-13-5-7-17-6-1-3-9-20(17)28/h1-4,6,8-10,16,24H,5,7,11-15H2,(H,25,29)
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PC sid
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Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...

Bioorg Med Chem Lett 23: 2590-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.108
BindingDB Entry DOI: 10.7270/Q2125V19
More data for this
Ligand-Target Pair