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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PAK 4' and Ligand = 'BDBM50251199'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM50251199
PNG
(CHEMBL4062257)
Show SMILES CC1CN(CC(C)N1)C(=O)c1nc(Nc2cc(C)[nH]n2)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C19H22ClN7O/c1-10-6-16(26-25-10)23-17-14-7-13(20)4-5-15(14)22-18(24-17)19(28)27-8-11(2)21-12(3)9-27/h4-7,11-12,21H,8-9H2,1-3H3,(H2,22,23,24,25,26)
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 119n/an/an/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human PAK4 kinase domain using coumarin and fluorescein-labeled ser/thr20 peptide as substrate preincubated for 15 mins followed by ATP...

J Med Chem 61: 265-285 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01342
BindingDB Entry DOI: 10.7270/Q2BK1FSN
More data for this
Ligand-Target Pair