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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PLK3' and Ligand = 'BDBM50343558'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))		BDBM50343558
PNG
(1-methyl-8-(5-(1-methylpiperidine-4-carboxamido)-2...)
Show SMILES CN1CCC(CC1)C(=O)Nc1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1
Show InChI InChI=1S/C25H27F3N8O3/c1-35-9-7-13(8-10-35)23(38)31-15-4-6-18(39-25(26,27)28)17(11-15)32-24-30-12-14-3-5-16-20(22(29)37)34-36(2)21(16)19(14)33-24/h4,6,11-13H,3,5,7-10H2,1-2H3,(H2,29,37)(H,31,38)(H,30,32,33)
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n/an/a 705n/an/an/an/an/an/a



Nerviano Medical Sciences srl

Curated by ChEMBL


Assay Description
Inhibition of PLK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting

Bioorg Med Chem Lett 21: 2969-74 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.054
BindingDB Entry DOI: 10.7270/Q27M088W
More data for this
Ligand-Target Pair