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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PLK3' and Ligand = 'BDBM50343563'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))		BDBM50343563
PNG
(1-(3-(dimethylamino)propyl)-8-(5-(4-methylpiperazi...)
Show SMILES CN(C)CCCn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(C)CC4)nc3-c12
Show InChI InChI=1S/C27H34F3N9O2/c1-36(2)9-4-10-39-24-19(23(35-39)25(31)40)7-5-17-16-32-26(34-22(17)24)33-20-15-18(38-13-11-37(3)12-14-38)6-8-21(20)41-27(28,29)30/h6,8,15-16H,4-5,7,9-14H2,1-3H3,(H2,31,40)(H,32,33,34)
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PC cid
PC sid
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Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Nerviano Medical Sciences srl

Curated by ChEMBL


Assay Description
Inhibition of PLK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting

Bioorg Med Chem Lett 21: 2969-74 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.054
BindingDB Entry DOI: 10.7270/Q27M088W
More data for this
Ligand-Target Pair