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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PLK3' and Ligand = 'BDBM50343566'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))		BDBM50343566
PNG
(1-methyl-8-(5-(3-(4-methylpiperazin-1-yl)propylami...)
Show SMILES CN1CCN(CCCNc2ccc(OC(F)(F)F)c(Nc3ncc4CCc5c(nn(C)c5-c4n3)C(N)=O)c2)CC1
Show InChI InChI=1S/C26H32F3N9O2/c1-36-10-12-38(13-11-36)9-3-8-31-17-5-7-20(40-26(27,28)29)19(14-17)33-25-32-15-16-4-6-18-22(24(30)39)35-37(2)23(18)21(16)34-25/h5,7,14-15,31H,3-4,6,8-13H2,1-2H3,(H2,30,39)(H,32,33,34)
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n/an/a 713n/an/an/an/an/an/a



Nerviano Medical Sciences srl

Curated by ChEMBL


Assay Description
Inhibition of PLK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting

Bioorg Med Chem Lett 21: 2969-74 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.054
BindingDB Entry DOI: 10.7270/Q27M088W
More data for this
Ligand-Target Pair