Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase SMG1' and Ligand = 'BDBM50394187'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase SMG1 (Homo sapiens (Human))	BDBM50394187 (CHEMBL2158850) Show SMILES COc1cccc(Nc2nccc(n2)-c2ccnc(c2)N2CCOCC2)c1 Show InChI InChI=1S/C20H21N5O2/c1-26-17-4-2-3-16(14-17)23-20-22-8-6-18(24-20)15-5-7-21-19(13-15)25-9-11-27-12-10-25/h2-8,13-14H,9-12H2,1H3,(H,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assay				Bioorg Med Chem Lett 22: 6636-41 (2012) Article DOI: 10.1016/j.bmcl.2012.08.107 BindingDB Entry DOI: 10.7270/Q2TB181N
					More data for this Ligand-Target Pair