BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase WNK1' and Ligand = 'BDBM50258581'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human))	BDBM50258581 (CHEMBL4070177) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL					Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph...				J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human))	BDBM50258581 (CHEMBL4070177) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL					Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph...				J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP
					More data for this Ligand-Target Pair