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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase WNK1' and Ligand = 'BDBM50258595'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase WNK1


(Homo sapiens (Human))		BDBM50258595
PNG
(CHEMBL4065531)
Show SMILES COc1cccc(c1)-c1cc(ccn1)-n1cc(CNCC2CCCCC2)c2ccccc12
Show InChI InChI=1S/C28H31N3O/c1-32-25-11-7-10-22(16-25)27-17-24(14-15-30-27)31-20-23(26-12-5-6-13-28(26)31)19-29-18-21-8-3-2-4-9-21/h5-7,10-17,20-21,29H,2-4,8-9,18-19H2,1H3
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n/an/a 60n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

Curated by ChEMBL


Assay Description
Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph...

J Med Chem 60: 7099-7107 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00708
BindingDB Entry DOI: 10.7270/Q29W0HXP
More data for this
Ligand-Target Pair