Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1' and Ligand = 'BDBM162015'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM162015 (US9682991, 71) Show SMILES CN1CCOc2c1c(N[C@H]1CC[C@H](N)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1 |r,wU:9.9,wD:12.13,(-6.57,2.69,;-5.24,3.47,;-5.24,5,;-3.91,5.78,;-2.57,5,;-2.57,3.47,;-3.91,2.69,;-3.91,1.15,;-5.24,.38,;-5.24,-1.15,;-3.91,-1.93,;-3.91,-3.47,;-5.24,-4.23,;-5.24,-5.78,;-6.57,-3.47,;-6.57,-1.93,;-2.57,.38,;-1.24,1.15,;.23,.68,;1.13,1.93,;.23,3.17,;-1.24,2.69,;.62,-.81,;-.46,-1.9,;-.07,-3.38,;1.42,-3.78,;2.51,-2.69,;4,-3.09,;5.09,-2,;6.57,-2.4,;4.69,-.52,;5.86,-3.34,;2.11,-1.21,)| Show InChI InChI=1S/C21H24F3N7O2/c1-30-9-10-32-17-16(30)18(26-14-7-5-13(25)6-8-14)29-31-19(27-28-20(17)31)12-3-2-4-15(11-12)33-21(22,23)24/h2-4,11,13-14H,5-10,25H2,1H3,(H,26,29)/t13-,14-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III US Patent					Assay Description The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...				US Patent US9682991 (2017) BindingDB Entry DOI: 10.7270/Q2513WCB
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