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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1' and Ligand = 'BDBM50258286'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50258286
PNG
(CHEMBL522497 | N-(piperidin-3-yl)-3-(3-(trifluorom...)
Show SMILES FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CCCNC3)nn12
Show InChI InChI=1S/C17H17F3N6/c18-17(19,20)12-4-1-3-11(9-12)16-24-23-15-7-6-14(25-26(15)16)22-13-5-2-8-21-10-13/h1,3-4,6-7,9,13,21H,2,5,8,10H2,(H,22,25)
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Similars
Article
PubMed
 94n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...

Bioorg Med Chem Lett 19: 3019-22 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.061
BindingDB Entry DOI: 10.7270/Q21J99PJ
More data for this
Ligand-Target Pair