new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Serotonin (5-HT) receptor' and Ligand = 'BDBM50145610'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50145610
PNG
(CHEMBL3764420)
Show SMILES Fc1ccc(cc1)N1CCN(CCCNC(=O)c2ccncc2)CC1
Show InChI InChI=1S/C19H23FN4O/c20-17-2-4-18(5-3-17)24-14-12-23(13-15-24)11-1-8-22-19(25)16-6-9-21-10-7-16/h2-7,9-10H,1,8,11-15H2,(H,22,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
0.228n/an/an/an/an/an/an/an/a



Dipartimento di Farmacia Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain cortex incubated for 15 mins by liquid scintillation counting analysis


Eur J Med Chem 110: 133-50 (2016)


BindingDB Entry DOI: 10.7270/Q24X59N9
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50145610
PNG
(CHEMBL3764420)
Show SMILES Fc1ccc(cc1)N1CCN(CCCNC(=O)c2ccncc2)CC1
Show InChI InChI=1S/C19H23FN4O/c20-17-2-4-18(5-3-17)24-14-12-23(13-15-24)11-1-8-22-19(25)16-6-9-21-10-7-16/h2-7,9-10H,1,8,11-15H2,(H,22,25)
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
99n/an/an/an/an/an/an/an/a



Dipartimento di Farmacia Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Sprague-Dawley rat brain cortex incubated for 30 mins by liquid scintillation counting analysis


Eur J Med Chem 110: 133-50 (2016)


BindingDB Entry DOI: 10.7270/Q24X59N9
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (Rat))
BDBM50145610
PNG
(CHEMBL3764420)
Show SMILES Fc1ccc(cc1)N1CCN(CCCNC(=O)c2ccncc2)CC1
Show InChI InChI=1S/C19H23FN4O/c20-17-2-4-18(5-3-17)24-14-12-23(13-15-24)11-1-8-22-19(25)16-6-9-21-10-7-16/h2-7,9-10H,1,8,11-15H2,(H,22,25)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Dipartimento di Farmacia Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine from 5HT2C receptor in Sprague-Dawley rat brain cortex incubated for 15 mins by liquid scintillation counting analysi...


Eur J Med Chem 110: 133-50 (2016)


BindingDB Entry DOI: 10.7270/Q24X59N9
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50145610
PNG
(CHEMBL3764420)
Show SMILES Fc1ccc(cc1)N1CCN(CCCNC(=O)c2ccncc2)CC1
Show InChI InChI=1S/C19H23FN4O/c20-17-2-4-18(5-3-17)24-14-12-23(13-15-24)11-1-8-22-19(25)16-6-9-21-10-7-16/h2-7,9-10H,1,8,11-15H2,(H,22,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Dipartimento di Farmacia Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Antagonist activity at 5HT2A receptor in Sprague-Dawley rat ileum assessed as inhibition of 5-HT-induced contraction


Eur J Med Chem 110: 133-50 (2016)


BindingDB Entry DOI: 10.7270/Q24X59N9
More data for this
Ligand-Target Pair