BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Signal transducer and activator of transcription 3' and Ligand = 'BDBM50446146'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50446146 (CHEMBL3108909) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Toronto at Mississauga Curated by ChEMBL					Assay Description Competitive binding affinity to STAT3 SH2 domain (unknown origin) assessed as inhibition of interaction with FAMpYLPQTV after 15 to 30 mins by fluore...				ACS Med Chem Lett 4: 1102-7 (2013) Article DOI: 10.1021/ml4003138 BindingDB Entry DOI: 10.7270/Q2D2202P
University of Toronto at Mississauga Curated by ChEMBL					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50446146 (CHEMBL3108909) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116941 BindingDB Entry DOI: 10.7270/Q2PN99MK
TBA					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Mus musculus (mouse))	BDBM50446146 (CHEMBL3108909) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Hawaii Cancer Center Curated by ChEMBL					Assay Description Inhibition of STAT3 DNA binding activity in mouse NIH/3T3 nuclear extract preincubated for 30 mins followed by [32P]hSIE addition measured after 30 m...				ACS Med Chem Lett 9: 250-255 (2018) Article DOI: 10.1021/acsmedchemlett.7b00544 BindingDB Entry DOI: 10.7270/Q2KH0R1M
University of Hawaii Cancer Center Curated by ChEMBL					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50446146 (CHEMBL3108909) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
University of Toronto at Mississauga Curated by ChEMBL					Assay Description Binding affinity to His-tagged STAT3 (unknown origin) by SPR spectroscopic analysis				ACS Med Chem Lett 4: 1102-7 (2013) Article DOI: 10.1021/ml4003138 BindingDB Entry DOI: 10.7270/Q2D2202P
University of Toronto at Mississauga Curated by ChEMBL					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 3 (Homo sapiens (Human))	BDBM50446146 (CHEMBL3108909) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.57E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00940 BindingDB Entry DOI: 10.7270/Q2H9999J
TBA					More data for this Ligand-Target Pair