BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/hydrogen exchanger 1' and Ligand = 'BDBM50115241'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/hydrogen exchanger 1


(Rattus norvegicus)		BDBM50115241
PNG
(CHEMBL541918 | N-[6-(2-chlorophenyl)-3-methyl-4,5,...)
Show SMILES Cc1n[nH]c2CC(CC(=NN=C(N)N)c12)c1ccccc1Cl |w:9.9,(-1.12,-2.5,;-.04,-3.6,;-.04,-5.14,;1.29,-5.93,;2.61,-5.14,;3.95,-5.91,;5.3,-5.14,;5.3,-3.6,;3.95,-2.83,;3.95,-1.29,;5.28,-.52,;5.28,1.02,;6.61,1.79,;3.94,1.79,;2.62,-3.6,;6.63,-5.91,;6.63,-7.45,;7.96,-8.22,;9.29,-7.45,;9.29,-5.91,;7.96,-5.14,;7.94,-3.6,)|
Show InChI InChI=1S/C15H17ClN6/c1-8-14-12(20-19-8)6-9(7-13(14)21-22-15(17)18)10-4-2-3-5-11(10)16/h2-5,9H,6-7H2,1H3,(H,19,20)(H4,17,18,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 55n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibition

J Med Chem 45: 3009-21 (2002)


BindingDB Entry DOI: 10.7270/Q2V40VZN
More data for this
Ligand-Target Pair