Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 5 subunit alpha' and Ligand = 'BDBM71063'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM71063 (US9546164, 208 | US9694002, 208) Show SMILES CCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)[C@@H](c2cc(Cl)cc(Cl)c2)C(C)(C)OC)cc1F |r| Show InChI InChI=1S/C29H37Cl2FN2O5S/c1-5-40(36,37)33-28(35)24-15-23(19-6-7-19)26(16-25(24)32)39-17-18-8-10-34(11-9-18)27(29(2,3)38-4)20-12-21(30)14-22(31)13-20/h12-16,18-19,27H,5-11,17H2,1-4H3,(H,33,35)/t27-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM71063 (US9546164, 208 | US9694002, 208) Show SMILES CCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)[C@@H](c2cc(Cl)cc(Cl)c2)C(C)(C)OC)cc1F |r| Show InChI InChI=1S/C29H37Cl2FN2O5S/c1-5-40(36,37)33-28(35)24-15-23(19-6-7-19)26(16-25(24)32)39-17-18-8-10-34(11-9-18)27(29(2,3)38-4)20-12-21(30)14-22(31)13-20/h12-16,18-19,27H,5-11,17H2,1-4H3,(H,33,35)/t27-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.2	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM71063 (US9546164, 208 | US9694002, 208) Show SMILES CCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)[C@@H](c2cc(Cl)cc(Cl)c2)C(C)(C)OC)cc1F |r| Show InChI InChI=1S/C29H37Cl2FN2O5S/c1-5-40(36,37)33-28(35)24-15-23(19-6-7-19)26(16-25(24)32)39-17-18-8-10-34(11-9-18)27(29(2,3)38-4)20-12-21(30)14-22(31)13-20/h12-16,18-19,27H,5-11,17H2,1-4H3,(H,33,35)/t27-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM71063 (US9546164, 208 | US9694002, 208) Show SMILES CCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)[C@@H](c2cc(Cl)cc(Cl)c2)C(C)(C)OC)cc1F |r| Show InChI InChI=1S/C29H37Cl2FN2O5S/c1-5-40(36,37)33-28(35)24-15-23(19-6-7-19)26(16-25(24)32)39-17-18-8-10-34(11-9-18)27(29(2,3)38-4)20-12-21(30)14-22(31)13-20/h12-16,18-19,27H,5-11,17H2,1-4H3,(H,33,35)/t27-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair