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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 9 subunit alpha' and Ligand = 'BDBM145246'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145246
PNG
(BDBM342437 | US8952169, 25)
Show SMILES CC1(C)[C@@H]2CC[C@@]1(C)[C@H](C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O |r|
Show InChI InChI=1/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)/t10-,15+,18+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 27n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145246
PNG
(BDBM342437 | US8952169, 25)
Show SMILES CC1(C)[C@@H]2CC[C@@]1(C)[C@H](C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O |r|
Show InChI InChI=1/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)/t10-,15+,18+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 27n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent




US Patent US9771376 (2017)


BindingDB Entry DOI: 10.7270/Q2W0983R
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145246
PNG
(BDBM342437 | US8952169, 25)
Show SMILES CC1(C)[C@@H]2CC[C@@]1(C)[C@H](C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O |r|
Show InChI InChI=1/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)/t10-,15+,18+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 220n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair