Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145285 (US8952169, 64 | US9771376, Example 64) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | 37 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145285 (US8952169, 64 | US9771376, Example 64) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc Curated by ChEMBL | Assay Description Inhibition of Nav1.7 (unknown origin) by electrophysiology assay | Bioorg Med Chem Lett 28: 3141-3149 (2018) Article DOI: 10.1016/j.bmcl.2018.08.007 BindingDB Entry DOI: 10.7270/Q2VD724S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145285 (US8952169, 64 | US9771376, Example 64) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ... | US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145285 (US8952169, 64 | US9771376, Example 64) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair |